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In conclusion, we were able to report among frail elderly residents that bolus vitamin D3 supplementation taken during or just before COVID-19 was associated with less severe COVID-19 and better survival rate. No other treatment showed protective effect.
Vitamin D3 supplementation may represent an effective, accessible and well-tolerated treatment for COVID-19, the incidence of which increases dramatically and for which there are currently no validated treatments. Further prospective, preferentially interventional, studies are needed to confirm whether supplementing older adults with bolus vitamin D3 during or just before the infection could improve, or prevent, COVID-19.